While incarcerated for murder, cartoonist Jack Deebs found escape by creating Cool World, a series featuring a voluptuous femme fatale named Holli Would. But the artist becomes a prisoner of his own fantasies when Holli transports Jack into Cool World with a scheme to seduce him and bring herself to life. Hard-boiled detective Frank Harris, the only other human in Cool World, cautions Jack with the law: Noids (humans) don't have sex with doodles (cartoons). However, flesh proves weaker than ink as Holli takes human form in Las Vegas, staring in a trans-universal chase that threatens the destruction of both worlds.