The second game in the Zero Escape series. Zero Escape: Virtue's Last Reward is a mystery/thriller visual novel. It is story focused with multiple endings that use player choices and puzzle rooms to progress.

Additions to the game include an 'auto-advance text' mode, so players can listen to the voice acting without clicking through dialog, a memo function that allows players to note anything they feel is useful, and a flow chart that shows how alternate choices unfold. The in-game calculator has been removed.